Assοciate Professor of Biochemistry
Tel. 2410 685578
e-mail: mylonis@uth.gr
Oxygen deficit activates adaptive mechanisms that induce the transcription of genes mainly orchestrated by HIF-1, whose oxygen-regulated subunit (HIF-1α) is frequently overexpressed in human cancers and correlated with poor outcomes. Our group aims to understand the fundamental mechanisms underlying the process by which hypoxia-inducible factor-1α (HIF-1α) or HIF-independed events reshape chromatin to coordinate the cellular response to changes in oxygen level. Our research interests include:
1) The investigation novel non-genomic functions of the transcription factor HIF-1α.
2) Targeted HIF-1 inhibition in cancer cells by cell permeable HIF-1α-derived peptides or cell signaling molecules.
3) The investigation of novel HIF-1α interaction partners that regulate HIF-dependent cell functions and gene selectivity under hypoxia.
4) HIF-independent, but hypoxia-mediated functions that influence nuclear processes or remodeling of chromatin.
Full List of Publications
https://pubmed.ncbi.nlm.nih.gov/?term=Mylonis+I